Why the study?
Does head-down tilt or ANP infusion affect renal function and plasma ANP levels in normal volunteers?
Does head-down tilt or ANP infusion affect renal function and plasma ANP levels in normal volunteers?
The lack of correlation between natriuretic response and plasma ANP levels suggests no direct cause-and-effect relationship between plasma ANP and sodium excretion during head-down tilt.
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Head-down tilt elicits natriuresis without proportional ANP elevation; challenges direct causal role of plasma ANP in volume regulation.
Allen et al. (1989) studied this question.
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