November 1, 1992American Journal of Hypertension

Relationship of the Renin-Angiotensin System and Systemic Arterial Pressure to Sodium Excretion During Atrial Natriuretic Peptide Infusion in Men

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Why the study?

Does the renin-angiotensin system and mean arterial pressure modulate sodium excretion and urine flow rate during atrial natriuretic peptide infusion in normal men?

Population

8 normal male volunteers

Comparison

Atrial natriuretic peptide infusion at… vs Baseline in the supine position

Authors

DGDonald J. GrandisUniversity of California, San Francisco BUBarry F. UretskyInterventional Cardiology JVJoseph G. VerbalisGeorgetown University

Discussion

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Implication

ANP natriuresis appears RAS-dependent in healthy subjects; hypothesis-generating for interactions in hypertension or HF.

Structured PICO

Does the renin-angiotensin system and mean arterial pressure modulate sodium excretion and urine flow rate during atrial natriuretic peptide infusion in normal men?

Population

8 normal male volunteers

Intervention

Atrial natriuretic peptide (ANP) infusion at physiologic doses (0.01 micrograms/kg/min) under various conditions (supine, 60 degrees head-up tilt, and with ACE inhibitor enalaprilat)

Comparator

Baseline in the supine position

Outcome

Sodium excretion and urine flow ratesurrogate

The natriuretic and diuretic effects of atrial natriuretic peptide are significantly modulated by the renin-angiotensin system and systemic arterial pressure.

Cite This Study

Grandis et al. (1992) studied this question.

synapsesocial.com/papers/6a98c797b0871bb756e108ba https://doi.org/10.1093/ajh/5.11.793

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Relationship of the Renin-Angiotensin System and Systemic Arterial Pressure to Sodium Excretion During Atrial Natriuretic Peptide Infusion in Men

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship of the Renin-Angiotensin System and Systemic Arterial Pressure to Sodium Excretion During Atrial Natriuretic Peptide Infusion in Men

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider