July 1, 1989Clinical Science
Atrial Natriuretic Peptide-Induced Decreases in Renal Blood Flow in Man: Implications for the Natriuretic Mechanism
Why the study?
Does low-dose infusion of atrial natriuretic peptide (ANP) alter renal blood flow and sodium excretion in healthy volunteers?
Population
Healthy volunteers
Follow-up
2 hours
Authors
Discussion
Loading...
Member takes
Implication
May implicate renal vasoconstriction in ANP natriuresis; hypothesis-generating in healthy volunteers only.
Structured PICO
Does low-dose infusion of atrial natriuretic peptide (ANP) alter renal blood flow and sodium excretion in healthy volunteers?
P
Population
Healthy volunteers
I
Intervention
Low-dose infusion of atrial natriuretic peptide (ANP)
O
Outcome
Renal blood flowsurrogate
Low-dose ANP infusion in healthy volunteers decreases renal blood flow and increases renal vascular resistance, suggesting intrarenal hemodynamic changes contribute to ANP-induced natriuresis.
Cite This Study
Janssen et al. (1989) studied this question.