Why the study?
Does head-up tilt induced hypovolemic shock alter atrial natriuretic peptide levels in healthy males?
Population
6 healthy males
Comparison
Head-up tilt to 50 degrees maintained until the… vs Baseline (pre-tilt)
Design
Other
Follow-up
35 +/- 7 min
Authors
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ANP falls during head-up tilt in healthy males; hypothesis-generating for volume-dependent regulation, should not yet change practice.
Does head-up tilt induced hypovolemic shock alter atrial natriuretic peptide levels in healthy males?
Changes in central blood volume, rather than central venous pressure, determine the secretion of atrial natriuretic peptide in humans.
Matzen et al. (1990) studied this question.
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