October 1, 1986AJP Regulatory Integrative and Comparative Physiology
Hypotension induced by passive head-up tilt: endocrine and circulatory mechanisms
Key result
Passive 60-degree head-up tilt induced a sudden hypotensive bradycardiac episode after 19±3 minutes, with MAP dropping from 94±3 to 50±8 mmHg and HR from 90±7 to 57±6 beats/min.
Why the study?
What are the endocrine and circulatory mechanisms of hypotension induced by passive head-up tilt in healthy young adults?
Population
7 healthy young adults
Comparison
30 and 60 degrees passive head-up tilt with… vs Baseline measurements prior to tilt
Design
Other
Follow-up
During tilt (up to approximately 19 minutes)
Authors
Discussion
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Implication
Offers a controlled model for vasovagal responses in healthy adults; leaves open translation to clinical syncope management.
Study Design
Type
Observational (n=7)
Structured PICO
What are the endocrine and circulatory mechanisms of hypotension induced by passive head-up tilt in healthy young adults?
P
Population
7 healthy young adults
I
Intervention
30 and 60 degrees passive head-up tilt with subjects supported by a saddle
C
Comparator
Baseline measurements prior to tilt
O
Outcome
Circulatory changes (pulse pressure, heart rate, mean arterial pressure) and arterial plasma hormone concentrationssurrogate
Passive head-up tilt to 60 degrees induces a reversible hypotensive bradycardiac episode accompanied by specific endocrine changes including increased vasopressin and pancreatic polypeptide.
Cite This Study
Sander-Jensen et al. (1986) conducted an observational in Healthy (n=7). Passive head-up tilt was evaluated on Circulatory changes and arterial plasma hormone concentrations. Passive 60-degree head-up tilt induced a sudden hypotensive bradycardiac episode after 19±3 minutes, with MAP dropping from 94±3 to 50±8 mmHg and HR from 90±7 to 57±6 beats/min.