March 1, 1973Clinical Science
Sympathetic Responsiveness to Head-Up Tilt in Essential Hypertension
Why the study?
Does 25° head-up tilt elicit different sympathetic and hemodynamic responses in untreated essential hypertensive patients compared to normotensive subjects?
Population
52 subjects: 41 untreated essential hypertensive patients and 11 normotensive subjects.
Comparison
25° head-up tilt vs Normotensive subjects undergoing the same tilt
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Exaggerated tilt responses may mark sympathetic overactivity in early hypertension; hypothesis-generating and should not change practice without prospective data.
Structured PICO
Does 25° head-up tilt elicit different sympathetic and hemodynamic responses in untreated essential hypertensive patients compared to normotensive subjects?
P
Population
52 subjects: 41 untreated essential hypertensive patients and 11 normotensive subjects.
I
Intervention
25° head-up tilt
C
Comparator
Normotensive subjects undergoing the same tilt
O
Outcome
Changes in blood pressure, urinary catecholamines, and creatinine clearancesurrogate
A subset of young, non-obese patients with recent-onset essential hypertension exhibits exaggerated sympathetic and hemodynamic responsiveness to orthostatic stress.
Cite This Study
Esler et al. (1973) studied this question.