Key result
Patients with mild-to-moderate essential hypertension exhibited a 17% increase in renal blood flow during a 60-degree head-up tilt, whereas normotensive controls had a 13% decrease (p<0.05).
Why the study?
Does head-up tilt elicit different renal haemodynamic and sympathetic responses in patients with mild-to-moderate essential hypertension compared to normotensive controls?
Population
18 subjects, comprising 9 patients with mild-to-moderate essential hypertension and 9 age-matched…
Comparison
Head-up tilt to 60 degrees for 10 minutes. vs Age-matched normotensive control subjects…
Design
Case-control
Follow-up
10 minutes
Authors
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Altered renal flow response to tilt in mild hypertension may reflect sympathetic dysregulation; hypothesis-generating and requires prospective validation.
Case-Control (n=18)
Does head-up tilt elicit different renal haemodynamic and sympathetic responses in patients with mild-to-moderate essential hypertension compared to normotensive controls?
Absolute Event Rate: 17% vs -13%
p-value: p=<0.05
Patients with mild-to-moderate essential hypertension exhibit enhanced systemic sympathetic and circulatory responses to orthostatic stress, but lack the normal compensatory increase in renal vascular resistance.
Westheim et al. (1990) conducted a case-control in Essential hypertension (n=18). Essential hypertension vs. Normotensive controls was evaluated on Change in renal blood flow during 60-degree head-up tilt (p=<0.05). Patients with mild-to-moderate essential hypertension exhibited a 17% increase in renal blood flow during a 60-degree head-up tilt, whereas normotensive controls had a 13% decrease (p<0.05).
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