October 1, 1986AJP Regulatory Integrative and Comparative Physiology
Cardiovascular and endocrine responses to head-up tilt and vasopressin infusion in humans
Key result
Small-angle nonhypotensive passive tilt did not affect vasopressin levels despite substantial reductions in central venous pressure and a marked fivefold increase in aldosterone (P<0.05).
Why the study?
Does passive head-up tilt and vasopressin infusion affect cardiovascular and endocrine responses in healthy young men?
Population
8 healthy young men
Design
Other
Follow-up
45 min
Authors
Discussion
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Implication
Challenges low-pressure baroreceptor control of vasopressin in health; leaves open relevance to orthostasis or HF.
Structured PICO
Does passive head-up tilt and vasopressin infusion affect cardiovascular and endocrine responses in healthy young men?
P
Population
8 healthy young men
I
Intervention
Passive head-up tilt (20 or 40 degrees for 45 min) and vasopressin infusion (0.25 or 1.0 ng/min/kg)
O
Outcome
Arterial and central venous pressures (MAP and CVP), heart rate (HR), arterial concentrations of vasopressin (AVP) and aldosterone (ALDO), osmolality, and hematocritsurrogate
Small-angle nonhypotensive passive tilt does not affect AVP measurably despite substantial reductions of CVP and a marked increase in ALDO, while AVP elevations elicit marked subcutaneous vasoconstriction.
Cite This Study
Bie et al. (1986) studied Healthy (n=8). Head-up tilt and vasopressin infusion was evaluated on Arterial and central venous pressures, heart rate, vasopressin, and aldosterone. Small-angle nonhypotensive passive tilt did not affect vasopressin levels despite substantial reductions in central venous pressure and a marked fivefold increase in aldosterone (P<0.05).