Key result
Static neck suction prevents the ~4-fold rise in plasma arginine vasopressin during head-up tilt.
Why the study?
The influence of carotid baroreflexes on plasma arginine vasopressin during head-up tilt in humans was not well understood.
Does stimulation of carotid baroreflexes by neck suction prevent the increase in plasma arginine vasopressin during head-up tilt in healthy males?
Comparison
Head-up tilt with vs without simultaneous static neck suction to stimulate carotid baroreflexes
Design
Sequence randomized controlled trial
Follow-up
15 minutes per session
Authors
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Neck suction blunts orthostatic vasopressin release in healthy men; confirms carotid baroreflex unloading as mediator and extends mechanistic research in autonomic regulation.
RCT (n=8)
Sequence randomized
Does stimulation of carotid baroreflexes by neck suction prevent the increase in plasma arginine vasopressin during head-up tilt in healthy males?
p-value: p=<0.05
Stimulation of carotid baroreflexes via neck suction blunts the increase in plasma vasopressin typically seen during head-up tilt, suggesting baroreceptor deloading mediates this response.
Kamegai et al. (1992) conducted an RCT in Healthy (n=8). Static neck suction during head-up tilt vs. Head-up tilt without neck suction was evaluated on Plasma arginine vasopressin (AVP) (p=<0.05). Static neck suction during head-up tilt prevented the significant increase in plasma arginine vasopressin observed during head-up tilt alone (from 1.0 to 4.2 pg/ml, P<0.05).
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