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October 1, 1985British Journal of PharmacologyOpen Access

Atrial natriuretic factor causes specific relaxation of rat renal arcuate arteries

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Population

Rat isolated renal arcuate arteries and resistance vessels of similar size from the mesenteric, femoral…

Comparison

Synthetic atrial natriuretic factor (ANF) vs Hydralazine, sodium nitroprusside, and baseline…

Design

Preclinical

Authors

CAChristian AalkjærVascular / Pulmonary VascularMMMichael J. MulvanyVascular / Pulmonary VascularNNNiels C. Berg NyborgNovo Nordisk (Denmark)

Discussion

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Implication

Renal-selective ANF relaxation in animals is hypothesis-generating; leaves open any human therapeutic relevance or translation.

Structured PICO

P
Population
Rat isolated renal arcuate arteries (lumen diameter ca. 250 microns) and resistance vessels of similar size from the mesenteric, femoral, cerebral and coronary vasculature
I
Intervention
Synthetic atrial natriuretic factor (ANF)
C
Comparator
Hydralazine, sodium nitroprusside, and baseline tone without ANF
O
Outcome
Vessel relaxationsurrogate

Synthetic ANF exerts a specific and prolonged relaxant effect on renal small arteries, likely mediated through specific receptors.

Cite This Study

Aalkjær et al. (1985) studied this question.

synapsesocial.com/papers/6a7e79a6dea41f5fbab7ba1ehttps://doi.org/10.1111/j.1476-5381.1985.tb08914.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Atrial natriuretic factor elicits an endothelium-independent relaxation and activates particulate guanylate cyclase in vascular smooth muscle.1984 · 496 citations
  2. 2An atrial peptide is a potent renal vasodilator substance.1984 · 125 citations
  3. 3Intrarenal localization of the natriuretic effect of cardiac atrial extract1982 · 228 citations
  4. 4Role of membrane potential in the response of rat small mesenteric arteries to exogenous noradrenaline stimulation.1982 · 154 citations
  5. 5ATRIAL NATRIURETIC FACTOR INHIBITS THE STIMULATION OF ALDOSTERONE SECRETION BY ANGIOTENSIN II, ACTH AND POTASSIUM<i>IN VITRO</i>AND ANGIOTENSIN II-INDUCED STEROIDOGENESIS<i>IN VIVO</i>.1984 · 273 citations