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August 11, 2026OxygenOpen Access

The Potential for Severe, Acute Inflammation to Impact Tissue Oxygenation—A Narrative Review

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Authors

ANAlan NimmoAYAlexander Younsi

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Overview

Narrative review explores how severe inflammation affects oxygen delivery in the body, suggesting potential therapies.

Key Points

  • The review aims to understand how severe acute inflammation affects tissue oxygenation through changes in vascular function.
  • Narrative review of existing literature on cardiovascular responses during acute inflammation.
  • Analysis of mechanisms such as vasodilation and increased vascular permeability.
  • Integration of case studies from conditions like sepsis to illustrate impacts on tissue oxygenation.
  • Severe inflammation leads to increased microvascular permeability, affecting oxygen diffusion.
  • Impairment of both micro- and macrocirculation results in decreased tissue perfusion.
  • Severe cases can lead to multiple organ system failure due to compromised oxygen delivery.

Cite This Study

Nimmo et al. (2026) studied this question.

synapsesocial.com/papers/6a7ae9663401087f2249e4e4https://doi.org/10.3390/oxygen6030022
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