Pooled results of two small trials with few events show a non-significant trend towards increased risk of intracerebral haemorrhage in people with Alzheimer's disease

Commentary on: Thoonsen H, Richard E, Bentham P, et al. Aspirin in Alzheimer's disease: increased risk of intracerebral hemorrhage: cause for concern? Stroke 2010;41:2690–2[OpenUrl][1][Abstract/FREE Full Text][2]. Alzheimer's disease (AD) is a neurodegenerative brain disease that leads to dementia. It is often accompanied by small vessel disease because of arteriosclerosis.1 AD and atherothrombosis share some common pathogenetic mechanisms which include chronic inflammation.2 Although the exact mechanism underlying this effect is still unknown, some have suggested aspirin use for patients with AD because of its anti-inflammatory properties.3 Thus aspirin use in AD has been considered by some researchers as a potential therapy for delaying the progression of AD through slowing of the neuroinflammatory response.4 … [1]: {openurl}?query=rft.jtitle%253DStroke%26rft_id%253Dinfo%253Adoi%252F10.1161%252FSTROKEAHA.109.576975%26rft_id%253Dinfo%253Apmid%252F20930165%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/ijlink?linkType=ABST&journalCode=strokeaha&resid=41/11/2690&atom=%2Febnurs%2F14%2F3%2F74.atom