Key result
Aspirin use after a first ischemic stroke in elderly patients was associated with a reduced risk of developing Alzheimer's disease at 5 years (HR 0.76; 95% CI 0.70-0.92).
Why the study?
Observational studies have shown inconsistent findings regarding the relationship between aspirin use and the risk of Alzheimer's disease.
Does aspirin therapy reduce the risk of a new diagnosis of Alzheimer's disease in elderly patients with ischemic stroke?
Cohort
Does aspirin therapy reduce the risk of a new diagnosis of Alzheimer's disease in elderly patients with ischemic stroke?
Hazard Ratio: 0.76 (95% CI 0.7–0.92)
Aspirin use following an ischemic stroke is associated with a significantly reduced risk of developing Alzheimer's disease in elderly patients.
Aspirin after ischemic stroke was associated with lower AD risk; leaves open whether it prevents Alzheimer's pending randomized trials.
BACKGROUND: Currently there are no effective therapies to prevent or halt the development of Alzheimer's disease (AD). Multiple risk factors are involved in AD, including ischemic stroke (IS). Aspirin is often prescribed following IS to prevent blood clot formation. Observational studies have shown inconsistent findings with respect to the relationship between aspirin use and the risk of AD. OBJECTIVE: To investigate the relationship between aspirin therapy after IS and the new diagnosis of AD in elderly patients. METHODS: This retrospective cohort study leveraged a large database that contains over 90 million electronic health records to compare the hazard rates of AD after IS in elderly patients prescribed aspirin versus those not prescribed aspirin after propensity-score matching for relevant confounders. RESULTS: At 1, 3, and 5 years after first IS, elderly patients prescribed aspirin were less likely to develop AD than those not prescribed aspirin: Hazard Ratio = 0.78 [0.65,0.94], 0.81 [0.70,0.94], and 0.76 [0.70,0.92]. CONCLUSION: Our findings suggest that aspirin use may prevent AD in patients with IS, a subpopulation at high risk of developing the disease.
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Gorenflo et al. (2022) conducted a cohort in Ischemic stroke. Aspirin vs. No aspirin was evaluated on New diagnosis of Alzheimer's disease (HR 0.76, 95% CI 0.70-0.92). Aspirin use after a first ischemic stroke in elderly patients was associated with a reduced risk of developing Alzheimer's disease at 5 years (HR 0.76; 95% CI 0.70-0.92).
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