Key result
Patients with stable heart failure and LVEF ≤ 0.35 had worse baseline diastolic function compared to those with LVEF between 0.35 and 0.45 (mean E' 4.6 vs. 6.1 cm/s; P<0.001).
RCT (n=102)
double-blind
randomized
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Diastolic assessment should complement LVEF in stable HF evaluation; confirms graded diastolic impairment across the systolic spectrum.
Willemsen et al. (2010) conducted an RCT in chronic heart failure (n=102). alagebrium vs. placebo was evaluated. Patients with stable heart failure and LVEF ≤ 0.35 had worse baseline diastolic function compared to those with LVEF between 0.35 and 0.45 (mean E' 4.6 vs. 6.1 cm/s; P<0.001).
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