April 11, 2007European Respiratory JournalOpen Access

Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD

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Population

22 individuals: 12 patients with chronic obstructive pulmonary disease and 10 healthy age-matched controls…

Design

Case-control

Authors

HGHarry R. GoskerMaastricht University Medical Centre MHMatthijs K. C. HesselinkMaastricht University Medical Centre HDHans DuimelMaastricht University Medical Centre

Discussion

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Implication

Muscle-specific mitochondrial depletion may underlie COPD exercise intolerance; leaves open causal role and therapeutic targeting.

Structured PICO

Population

22 individuals: 12 patients with chronic obstructive pulmonary disease (COPD) and 10 healthy age-matched controls. Vastus lateralis biopsies were obtained from 6 COPD patients and 4 controls; tibialis anterior biopsies from 6 COPD patients and 6 controls.

Comparator

Healthy age-matched controls

Outcome

Mitochondrial number, fractional area, morphometry, and Z-line width assessed by transmission electron microscopysurrogate

Reduced mitochondrial fractional area in the vastus lateralis likely contributes to decreased oxidative capacity and exercise intolerance in COPD patients, whereas it is maintained in the tibialis anterior.

Cite This Study

Gosker et al. (2007) studied this question.

synapsesocial.com/papers/6a7b086d8d250a4360f449a5 https://doi.org/10.1183/09031936.00146906

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Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider