Key result
Continuing ACEI or ARA on the day of surgery caused significant reductions in systolic, diastolic, and mean arterial pressures up to 60 minutes after induction of general anesthesia compared to withholding them.
Why the study?
Does preoperative discontinuation of ACEI or ARA prevent intraoperative hypotension in hypertensive patients undergoing general anesthesia?
Population
60 hypertensive patients aged 40-60 years, ASA grade II and III, receiving only angiotensin-converting…
Comparison
Discontinuation of angiotensin-converting enzyme… vs Continuation of angiotensin-converting enzyme…
Design
RCT, Randomized by sealed envelope technique into two equal groups, Double…
Follow-up
60 minutes post-induction
Authors
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Withholding ACEI/ARA preoperatively may reduce post-induction hypotension; supports discontinuation in hypertensive patients undergoing general anesthesia.
RCT (n=60)
Double-blind
Sealed envelope technique
No
Does preoperative discontinuation of ACEI or ARA prevent intraoperative hypotension in hypertensive patients undergoing general anesthesia?
p-value: p=<0.01
Discontinuing ACEI or ARA the day before surgery safely prevents significant intraoperative hypotension during general anesthesia.
Rajan et al. (2014) conducted an RCT in Hypertension (n=60). Discontinuation of ACEI or ARA vs. Continuation of ACEI or ARA was evaluated on Intra-operative systolic, diastolic, and mean arterial pressures after induction of general anesthesia (p=<0.01). Continuing ACEI or ARA on the day of surgery caused significant reductions in systolic, diastolic, and mean arterial pressures up to 60 minutes after induction of general anesthesia compared to withholding them.
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