Key result
Doxorubicin induced a fourfold higher level of cardiomyocyte apoptosis in 1-week-old neonatal mice compared with 3-week-old adult mice, revealing a critical transition from high to low susceptibility during postnatal heart maturation.
Population
Wild-type FVB mice and transgenic mice (α-MHC-nLacZ) at progressive ages from neonatal to 5 weeks old
Comparison
Single dose of doxorubicin administered… vs Same volume of saline administered at the same…
Design
Preclinical
Follow-up
24 hours
Authors
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Neonatal anthracycline exposure may warrant heightened caution; leaves open whether postnatal maturation windows translate to human pediatric dosing.
p-value: p=<0.05
Neonatal mouse hearts exhibit a significantly higher susceptibility to doxorubicin-induced apoptosis compared to adult hearts, driven by a rapid postnatal downregulation of key proapoptotic proteins.
Shi et al. (2012) studied Doxorubicin-induced cardiotoxicity. Doxorubicin vs. Saline was evaluated on Cardiomyocyte apoptosis (cleaved caspase-3 and TUNEL positivity) (p=<0.05). Doxorubicin induced a fourfold higher level of cardiomyocyte apoptosis in 1-week-old neonatal mice compared with 3-week-old adult mice, revealing a critical transition from high to low susceptibility during postnatal heart maturation.
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