January 26, 2010PEDIATRICS
Sibling Transmission of Vaccine-Derived Rotavirus (RotaTeq) Associated With Rotavirus Gastroenteritis
Key result
Transmission of vaccine-derived rotavirus (RotaTeq) from a vaccinated infant to an unvaccinated older sibling resulted in symptomatic rotavirus gastroenteritis requiring emergency department care.
Population
2 children (a vaccinated infant and an older, unvaccinated sibling) without underlying medical conditions
Design
Case_report
Follow-up
11 months
Authors
Discussion
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Member takes
Implication
Alerts clinicians to rare household transmission risk; leaves open incidence, severity, and vaccination policy implications.
Study Design
Type
Case Report (n=2)
Structured PICO
P
Population
Two siblings (a vaccinated infant and an older unvaccinated sibling) followed for 11 months after transmission of vaccine-derived rotavirus.
E
Exposure
Rotavirus vaccine (RotaTeq) administered to the infant
O
Outcome
Symptomatic rotavirus gastroenteritis in the unvaccinated sibling requiring emergency department caresafety
This case documents the first reported instance of symptomatic rotavirus gastroenteritis resulting from sibling transmission of vaccine-derived rotavirus.
Cite This Study
Payne et al. (2010) conducted a case report in Rotavirus gastroenteritis (n=2). Vaccine-derived rotavirus (RotaTeq) transmission was evaluated on Symptomatic rotavirus gastroenteritis requiring emergency department care. Transmission of vaccine-derived rotavirus (RotaTeq) from a vaccinated infant to an unvaccinated older sibling resulted in symptomatic rotavirus gastroenteritis requiring emergency department care.