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May 9, 2009AJP Heart and Circulatory PhysiologyOpen Access

Overexpression of CYP2J2 provides protection against doxorubicin-induced cardiotoxicity

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Population

Transgenic mice with cardiomyocyte-specific overexpression of human CYP2J2 and wild-type littermate…

Comparison

Doxorubicin administration vs Vehicle control and wild-type mice

Design

Preclinical, Mice were randomly divided into three groups, All studies were…

Follow-up

Acute: 4 days; Chronic: 7 weeks

Authors

YZYunfang ZhangHEHaitham El‐SikhryKCKetul R. Chaudhary

Discussion

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Overview

Should not change clinical practice; hypothesis-generating for CYP2J2 cardioprotection in anthracycline toxicity.

Structured PICO

P
Population
Transgenic mice with cardiomyocyte-specific overexpression of human CYP2J2 and wild-type littermate controls (male and female, aged 3-5 months, 25-35 g); H9c2 cells.
I
Intervention
Doxorubicin administration (acute: 5 or 15 mg/kg daily for 3 days; chronic: 1.5 or 3.0 mg/kg biweekly for 5 weeks)
C
Comparator
Vehicle control (0 mg/kg doxorubicin) and wild-type mice
O
Outcome
Cardiotoxicity assessed by serum lactate dehydrogenase (LDH), creatine kinase (CK), apoptosis (caspase-3, TUNEL), and cardiac function (fractional shortening)surrogate

Cardiomyocyte-specific overexpression of CYP2J2 limits doxorubicin-induced cardiotoxicity and preserves cardiac function in mice, partially by improving doxorubicin metabolism and preserving mitochondrial function.

Cite This Study

Zhang et al. (2009) studied this question.

synapsesocial.com/papers/6a7b1bf45968508e56f3f131https://doi.org/10.1152/ajpheart.00983.2008
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CYP2J2-derived epoxyeicosatrienoic acids protect against doxorubicin-induced cardiotoxicity by reducing oxidative stress and apoptosis via activation of the AMPK pathway2023 · 5 citations
  2. 2CYP2J2 Overexpression Protects against Arrhythmia Susceptibility in Cardiac Hypertrophy2013 · 62 citations
  3. 3Inhibition of Cyp1a Protects Mice against Anthracycline Cardiomyopathy2024
  4. 4Cardiomyocyte-specific expression of CYP2J2 prevents development of cardiac remodelling induced by angiotensin II2015 · 67 citations
  5. 5Sex-dependent alteration of cardiac cytochrome P450 gene expression by doxorubicin in C57Bl/6 mice2017 · 54 citations