This review highlights the mechanisms by which African swine fever virus genes regulate apoptosis to promote viral replication and pathogenesis.
May inform ASFV control strategies in swine; leaves open functional validation of gene targets.
A number of viruses have evolved antiapoptotic mechanisms to promote infected-cell survival, either to ensure efficient productive viral replication or to promote long-term survival of virus-infected cells. Recent studies identified critical African swine fever virus genes involved in the complex regulation of ASFV-host interactions. Here we review the present knowledge of the recently identified ASFV genes with special attention to those which affect viral virulence, host range, and pathogenesis by regulating viral-induced apoptotic mechanisms.
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Zsak et al. (2002) studied this question.
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