What question did this study set out to answer?

To determine whether pharmacological inhibition of connective tissue growth factor (CTGF) attenuates cardiac fibrosis and improves myocardial repair following myocardial infarction.

February 1, 2019JACC Basic to Translational ScienceOpen Access

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

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Authors

LVLaura VainioUniversity of Helsinki ZSZoltán SzabóOulu University Hospital RLRuizhu LinUniversity of Arizona

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Implication

Animal study shows CTGF monoclonal antibody therapy limits fibrosis and boosts survival in mice after myocardial infarction, suggesting a novel target for post-infarct repair.

Key Points

To determine whether pharmacological inhibition of connective tissue growth factor (CTGF) attenuates cardiac fibrosis and improves myocardial repair following myocardial infarction.
Treated mice with a CTGF monoclonal antibody during infarct repair, post-myocardial infarction left ventricular remodeling, or acute ischemia-reperfusion injury.
Assessed survival, left ventricular dysfunction, ventricular hypertrophy, and extent of cardiac fibrosis.
Analyzed transcriptional alterations in cardiac developmental, repair, inflammatory, and fibrotic gene pathways.
CTGF monoclonal antibody administration during infarct repair improved overall survival and significantly attenuated left ventricular dysfunction.
Therapy reduced post-infarction left ventricular hypertrophy and fibrotic tissue deposition.
Inhibition of CTGF promoted the expression of cardiac repair and developmental genes while suppressing inflammatory and fibrotic signaling pathways.

Cite This Study

Vainio et al. (2019) studied this question.

synapsesocial.com/papers/6a7b25f34c448619ca0e6785 https://doi.org/10.1016/j.jacbts.2018.10.007

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Implication

Animal study shows CTGF monoclonal antibody therapy limits fibrosis and boosts survival in mice after myocardial infarction, suggesting a novel target for post-infarct repair.

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

Connective Tissue Growth Factor Inhibition Enhances Cardiac Repair and Limits Fibrosis After Myocardial Infarction

Discussion

Member takes

Implication

Key Points

Cite This Study

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