Key result
A systematic review of 132 studies identified associations between psychosocial, socioeconomic, clinical, and treatment-related factors and outcomes in patients with aortic stenosis undergoing TAVI.
Why the study?
Patient risk stratification and accurate tools are crucial for identifying suitable TAVI candidates, prompting a summary of how selected factors influence outcomes in patients with AS undergoing TAVI.
What factors influence the outcomes of patients with aortic stenosis undergoing transcatheter aortic valve implantation?
Systematic Review (n=132)
What factors influence the outcomes of patients with aortic stenosis undergoing transcatheter aortic valve implantation?
A systematic review of 132 studies highlights the multifactorial influence on TAVI outcomes, emphasizing the need for a comprehensive predictive tool.
Backround/Objectives: Aortic stenosis (AS) is the most commonly acquired valvular disorder. Patient risk stratification and the development of an accurate and reliable tool are crucial in identifying suitable candidates for TAVI. The present review summarized the current state of knowledge on the influence of selected factors on the outcomes and course of patients with AS undergoing transcatheter aortic valve implantation (TAVI). Methods: The inclusion criteria for the present systematic review were as follows: (1) studies indexed in the medical databases PubMed, MEDLINE, EMBASE, CINAHL, Web of Science, and Scopus; (2) full-text articles available in English; (3) papers published between 2013 and 2023; and (4) addressing the topic of assessing the impact of factors on the outcomes of patients with aortic stenosis undergoing TAVI. This review used PRISMA 2020 reporting guidelines for systematic reviews and meta-analyses. Results: One hundred and thirty-two studies were eligible for this review. The available studies showed an association of psychosocial and socioeconomic factors, valve parameters, comorbidities, clinical factors, treatment-related factors, biomarkers, and treatment methods with the outcomes of patients with AS undergoing TAVI. Conclusions: Given the conflicting results obtained regarding the impact of right ventricular dysfunction, paravalvular leaks, and treatment method on the mortality of patients undergoing aortic valve implantation, further research in these areas is needed. In view of the researchers’ differing views on some of the factors affecting patient outcomes after TAVI, further analysis is needed to develop a new tool for assessing predictive outcomes in AS patients. This study is registered at PROSPERO (CRD42024612752).
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Świątoniowska-Lonc et al. (2025) conducted a systematic review in Aortic stenosis undergoing TAVI (n=132). Various factors (psychosocial, socioeconomic, clinical, comorbidities, biomarkers, treatment methods) was evaluated on Patient outcomes and course after TAVI. A systematic review of 132 studies identified associations between psychosocial, socioeconomic, clinical, and treatment-related factors and outcomes in patients with aortic stenosis undergoing TAVI.
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