Key result
Skin sodium storage and immune system regulation via macrophages act as extrarenal regulatory mechanisms essential for maintaining extracellular sodium, volume, and blood pressure homeostasis.
Design
Review
Authors
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May inform macrophage-targeted hypertension research; leaves open clinical translation pending prospective human trials.
This review highlights that blood pressure and volume homeostasis rely on extrarenal mechanisms, specifically sodium storage in the skin interstitium regulated by the immune system.
Titze et al. (2010) conducted a review in Hypertension. Extrarenal sodium regulatory mechanisms was evaluated. Skin sodium storage and immune system regulation via macrophages act as extrarenal regulatory mechanisms essential for maintaining extracellular sodium, volume, and blood pressure homeostasis.
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