Key result
Proteomic analysis of plasma from patients with various cardiovascular diseases identified 128 uniquely regulated proteins, including 49 novel biomarker candidates.
Cross-Sectional (n=178)
No
Proteomic profiling identified 128 unique plasma biomarker candidates across different cardiovascular diseases, offering potential new targets for risk stratification and pathophysiological understanding.
May represent novel CVD biomarkers; leaves open validation and clinical utility in prospective studies.
In-depth proteome discovery analysis represents new strategy in an effort to identify novel reliable specific protein markers for hypertrophic cardiomyopathy and other life threatening cardiovascular diseases. To systematically identify novel protein biomarkers of cardiovascular diseases with high mortality we employed an isobaric tag for relative and absolute quantitation (iTRAQ) proteome technology to make comparative analysis of plasma samples obtained from patients suffering from non-obstructive hypertrophic cardiomyopathy, stable dilated cardiomyopathy, aortic valve stenosis, chronic stable coronary artery disease and stable arterial hypertension. We found 128 plasma proteins whose abundances were uniquely regulated among the analyzed cardiovascular pathologies. 49 of them have not been described yet. Additionally, application of statistical exploratory analyses of the measured protein profiles indicated the relationship in pathophysiology of the examined cardiovascular pathologies.
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Řehulková et al. (2016) conducted a cross-sectional in Cardiovascular diseases (Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy, Coronary Artery Disease, Aortic Stenosis, Arterial Hypertension) (n=178). Cardiovascular diseases vs. Healthy controls was evaluated on Differentially expressed plasma proteins uniquely regulated among cardiovascular pathologies. Proteomic analysis of plasma from patients with various cardiovascular diseases identified 128 uniquely regulated proteins, including 49 novel biomarker candidates.
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