March 4, 2005AJP Heart and Circulatory Physiology
Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin
Why the study?
Does ganglionic blockade and oscillatory LBNP reveal differential dynamic autoregulation in glabrous versus nonglabrous skin?
Population
10 subjects
Comparison
Ganglionic blockade via intravenous trimethaphan… vs Baseline condition
Design
Other
Authors
Discussion
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Member takes
Implication
Differential skin autoregulation persists after ganglionic blockade; leaves open translation to clinical vasomotor monitoring.
Structured PICO
Does ganglionic blockade and oscillatory LBNP reveal differential dynamic autoregulation in glabrous versus nonglabrous skin?
P
Population
10 subjects
I
Intervention
Ganglionic blockade via intravenous trimethaphan administration, and trimethaphan plus oscillatory lower body negative pressure (LBNP; -5 to -10 mmHg) from 0.05 to 0.07 Hz
C
Comparator
Baseline condition
O
Outcome
Spectral power and transfer function gain between blood pressure and skin blood flow in glabrous (palm) and nonglabrous (forearm) regionssurrogate
Independent of neural control, glabrous skin demonstrates dynamic autoregulation to buffer blood pressure oscillations, whereas nonglabrous skin has diminished autoregulatory capabilities.
Cite This Study
Wilson et al. (2005) studied this question.