July 23, 2004RNAOpen Access

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

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Population

Genomes of positive-stranded animal and plant RNA viruses

Design

Preclinical

Authors

PSPeter SimmondsGoethe University Frankfurt ATAndrew TuplinUniversity of Leeds DEDavid J. EvansUniversity of Oxford

Discussion

Member takes

Implication

Hypothesis-generating for GORS in viral persistence; leaves open its role in modulating innate defenses pending human validation.

Structured PICO

Population

Genomes of positive-stranded animal and plant RNA viruses (including Picornaviridae, Flaviviridae, and Caliciviridae)

Intervention

Bioinformatics analysis methods to identify genome-scale ordered RNA structure (GORS)

Outcome

Presence of genome-scale ordered RNA structure (GORS) and its correlation with host persistence

The presence of genome-scale ordered RNA structure in positive-strand RNA viruses correlates with host persistence, suggesting a potential role in modulating innate intracellular defense mechanisms.

Cite This Study

Simmonds et al. (2004) studied this question.

synapsesocial.com/papers/6a7b4f34684c0941cf326230 https://doi.org/10.1261/rna.7640104

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Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses: Implications for virus evolution and host persistence

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider