September 18, 2008Journal of VirologyOpen Access

Bioinformatic and Physical Characterizations of Genome-Scale Ordered RNA Structure in Mammalian RNA Viruses

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Population

Mammalian RNA viruses and rRNA sequences

Comparison

Bioinformatic analysis and physical… vs Unstructured virus transcripts and rRNA…

Design

Preclinical

Authors

MDMatthew P. DavisUniversity of Leeds SSSelena M. SaganUniversity of British Columbia JPJohn Paul PezackiUniversity of Ottawa

Discussion

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Implication

May influence flavivirus persistence via RNA structure; leaves open effects on host defenses in human infection.

Structured PICO

Population

Mammalian RNA viruses (including HCV, HGV/GBV-C, murine norovirus, poliovirus, rubella virus) and rRNA sequences

Intervention

Bioinformatic analysis (thermodynamic methods, RNAz, Pfold) and physical characterization (probe hybridization accessibility assay, atomic force microscopy)

Comparator

Unstructured virus transcripts and rRNA sequences as controls

Outcome

RNA secondary structure and physical configurationsurrogate

Bioinformatic and physical characterization methods identified fundamental differences in the configurations of viral genomic RNA that may modify their interactions with host cell defenses and persistence.

Cite This Study

Davis et al. (2008) studied this question.

synapsesocial.com/papers/6a7e3d8bfff4c9ddccc76760 https://doi.org/10.1128/jvi.01078-08

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Bioinformatic and Physical Characterizations of Genome-Scale Ordered RNA Structure in Mammalian RNA Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bioinformatic and Physical Characterizations of Genome-Scale Ordered RNA Structure in Mammalian RNA Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider