Key result
Exposure to drug-drug and drug-disease interactions in older people is associated with increased risks of hospitalization and adverse drug events, though empirical data on clinical outcomes remain limited.
Drug-drug and drug-disease interactions are common in older people and are associated with adverse clinical outcomes, highlighting the importance of considering interactions with geriatric syndromes.
May support interaction screening in older adults; leaves open prospective validation of clinical outcomes.
This clinical review summarizes the evidence in relation to clinical outcomes from drug-drug and drug-disease interactions in older people. Exposure to drug-drug interactions is associated with increased risk of hospitalization-related outcomes in older people. Drug-disease interactions have been linked with adverse drug interactions and adverse drug events in studies of older people. Although the prevalence of drug-drug and drug-disease interactions is common in older people, there are very limited empirical data on important clinical outcomes from drug-drug and drug-disease interactions. Clinical implications of interactions between drugs and geriatric syndromes such as frailty, falls, cognitive impairment, immobility and urinary incontinence should also be considered in older people.
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Gnjidic et al. (2013) conducted a review in Drug-drug and drug-disease interactions. Drug-drug and drug-disease interactions was evaluated on Clinical outcomes (hospitalization, adverse drug events). Exposure to drug-drug and drug-disease interactions in older people is associated with increased risks of hospitalization and adverse drug events, though empirical data on clinical outcomes remain limited.
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