Key result
Pre-eclampsia was associated with a significantly lower reactive hyperaemia index (median 1.70 vs 1.81, p=0.0269) and higher augmentation index compared to normotensive pregnancy, demonstrating endothelial dysfunction and arterial stiffness.
Why the study?
Does the EndoPAT method demonstrate endothelial dysfunction and arterial stiffness in pre-eclampsia compared to normotensive controls?
Case-Control (n=215)
No
Does the EndoPAT method demonstrate endothelial dysfunction and arterial stiffness in pre-eclampsia compared to normotensive controls?
Absolute Event Rate: 1.7% vs 1.81%
p-value: p=0.0269
The EndoPAT method can non-invasively detect endothelial dysfunction and increased arterial stiffness in women with pre-eclampsia.
May support postpartum vascular monitoring after pre-eclampsia; hypothesis-generating for long-term cardiovascular risk.
OBJECTIVES: The EndoPAT method has been used as a non-invasive method for assessing endothelial function in several non-pregnant populations. We investigated its possible use in assessing endothelial dysfunction in pre-eclampsia. METHODS: Two hundred and fifteen participants were recruited and grouped as pre-eclamptic cases (105) and normotensive controls (110). Endothelial function and arterial stiffness were measured as reactive hyperaemia index and augmentation index, respectively, using the EndoPAT 2000 machine. RESULTS: The reactive hyperaemia index was significantly lower in the pre-eclamptic group compared to the normotensive group (p < 0.05). Augmentation index on the other hand was significantly higher in the pre-eclamptic group compared to the normotensive group (p < 0.0001). CONCLUSION: The EndoPAT method demonstrates endothelial dysfunction and arterial stiffness in pre-eclampsia.
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Meeme et al. (2017) conducted a case-control in Pre-eclampsia (n=215). Pre-eclampsia vs. Normotensive pregnancy was evaluated on Reactive hyperaemia index (RHI) (p=0.0269). Pre-eclampsia was associated with a significantly lower reactive hyperaemia index (median 1.70 vs 1.81, p=0.0269) and higher augmentation index compared to normotensive pregnancy, demonstrating endothelial dysfunction and arterial stiffness.
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