Key result
Preeclampsia was associated with deteriorated arterial stiffness, altered endothelial function, and abnormal angiogenic biomarkers compared with healthy pregnancy.
Why the study?
Do peripheral arterial tonometry and angiogenic biomarkers provide diagnostic value for preeclampsia in pregnant women?
Observational
Do peripheral arterial tonometry and angiogenic biomarkers provide diagnostic value for preeclampsia in pregnant women?
Peripheral arterial analysis provides additional diagnostic information beyond serum biomarkers for identifying preeclampsia.
These vascular changes in preeclampsia should not yet alter care; leaves open their utility for long-term risk prediction.
OBJECTIVE: To evaluate changes in vascular function and serum biomarkers in women with and without preeclampsia (PE) to create a model for the easier and more precise diagnosis of PE in the future. METHODS: Endothelial function and arterial stiffness were evaluated using peripheral arterial tonometry and concentrations of placental growth factor (PlGF), soluble fms like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng) were determined by immunoassay. RESULTS: Arterial stiffness deteriorates and endothelial function is better in women with PE compared with a healthy pregnancy. Women who developed PE had a decreased PlGF and PlGF/(sFlt-1+ sEng) ratio and an increased sEng, and sFlt-1/PlGF ratio. CONCLUSION: Peripheral arterial analysis did provide additional information beyond serum biomarkers in the diagnosis of PE.
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Kumer et al. (2018) conducted an observational in Preeclampsia. Preeclampsia vs. Healthy pregnancy was evaluated on Endothelial function, arterial stiffness, and serum biomarkers (PlGF, sFlt-1, sEng). Preeclampsia was associated with deteriorated arterial stiffness, altered endothelial function, and abnormal angiogenic biomarkers compared with healthy pregnancy.
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