What question did this study set out to answer?

To determine whether central administration of oxyntomodulin and related proglucagon-derived peptides influences feeding behavior in rats.

October 1, 2001EndocrinologyOpen Access

Oxyntomodulin Inhibits Food Intake in the Rat

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Authors

CDC. L. DakinUniversity of British Columbia IGI. Gunn CSC. J. SmallPalmetto Hematology Oncology

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Implication

Preclinical animal study demonstrates central oxyntomodulin suppresses food intake in fasted and nonfasted rats, suggesting an appetite-regulating role in the central nervous system.

Key Points

To determine whether central administration of oxyntomodulin and related proglucagon-derived peptides influences feeding behavior in rats.
Administered oxyntomodulin, glucagon, glicentin, and spacer peptide-1 via intracerebroventricular or hypothalamic paraventricular nucleus injection in 24-hour fasted rats and nonfasted rats at dark phase onset.
Assessed receptor mechanisms by coadministering the glucagon-like peptide-1 receptor antagonist exendin-(9-39) and measuring glucagon-like peptide-1 receptor binding affinity.
Oxyntomodulin (1 nmol) significantly reduced 1-hour food intake in 24-hour fasted rats versus saline when delivered intracerebroventricularly and into the paraventricular nucleus (3.1 ± 0.5 g vs. 6.2 ± 0.4 g, P < 0.005).
Intracerebroventricular oxyntomodulin (3 nmol) significantly suppressed 1-hour feeding in nonfasted rats at dark phase onset compared to saline (1.1 ± 0.19 g vs. 2.3 ± 0.2 g, P < 0.05).
The anorectic action of oxyntomodulin was blocked by exendin-(9-39), despite oxyntomodulin displaying lower affinity for the glucagon-like peptide-1 receptor than glucagon-like peptide-1 itself (IC50: 8.2 nM vs. 0.16 nM).

Cite This Study

Dakin et al. (2001) studied this question.

synapsesocial.com/papers/6a7b54fc2eb3c7e469f44b68 https://doi.org/10.1210/endo.142.10.8430

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Implication

Preclinical animal study demonstrates central oxyntomodulin suppresses food intake in fasted and nonfasted rats, suggesting an appetite-regulating role in the central nervous system.

Oxyntomodulin Inhibits Food Intake in the Rat

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Implication

Key Points

Cite This Study

Oxyntomodulin Inhibits Food Intake in the Rat

Discussion

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Implication

Key Points

Cite This Study

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