Why the study?
Does the combination of thioridazine and tricyclic antidepressants cause life-threatening ventricular arrhythmias?
Does the combination of thioridazine and tricyclic antidepressants cause life-threatening ventricular arrhythmias?
The combination of thioridazine and tricyclic antidepressants can cause life-threatening ventricular arrhythmias due to synergistic adverse effects on cardiac repolarization.
Alerts to potential arrhythmia risk with thioridazine plus tricyclics; case reports leave causality and practice change open.
Thioridazine-tricyclic antidepressant combination is frequently used in clinical practice. One reason for the choice of this combination may be its anticipated effectiveness in depressions which show both retarded and anxious features. Because both of these drugs have an adverse effect on cardiac repolarization, this may be a particularly hazardous combination. Two cases are presented illustrating life-threatening ventricular arrythmia in patients who have ingested both thioridazine and tricyclic antidepressants.
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Elliott M. Heiman (1977) studied this question.
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