Population
Adult rat ventricular myocytes in culture
Comparison
Nitric oxide donor S-nitroso-N-acetylpenicillamin… vs N-acetylpenicillamine or SNAP + reduced hemoglobin
Design
Preclinical
Authors
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NO-p53 apoptosis link in rat myocytes is hypothesis-generating; clinical relevance in human heart disease remains unproven.
Nitric oxide triggers apoptosis in adult rat ventricular myocytes, suggesting a mechanism for NO-mediated cardiac myocyte death involving p53.
Pinsky et al. (1999) studied this question.
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