Why the study?
Is clopidogrel superior to aspirin in preventing adverse events post coronary arterial bypass grafting?
Is clopidogrel superior to aspirin in preventing adverse events post coronary arterial bypass grafting?
Clopidogrel is an acceptable alternative to aspirin post-CABG if aspirin is not tolerated, but lacks strong evidence of superiority.
Clopidogrel not superior to aspirin post-CABG; confirms aspirin preference with clopidogrel as alternative only for intolerance.
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether clopidogrel is superior to aspirin in preventing adverse events post coronary arterial bypass grafting. Altogether 220 papers were found using the reported search, of which four presented the best evidence to answer the clinical question. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results, and study weaknesses of these papers are tabulated. We conclude that if aspirin is not tolerated, clopidogrel is an acceptable alternative, but there is no strong evidence that clopidogrel is superior to aspirin postcoronary surgery.
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Darbhamulla V. Nagarajan (2004) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: