Why the study?
Does intraarterial infusion of nebivolol reduce pulse wave velocity in an anesthetized sheep model compared to atenolol?
Population
Anesthetized sheep (local, ovine, hind-limb model)
Comparison
Intraarterial infusion of nebivolol vs Intraarterial infusion of atenolol
Design
Preclinical
Authors
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Suggests nebivolol improves arterial distensibility via NO in sheep; leaves open relevance to human hypertension therapy.
Does intraarterial infusion of nebivolol reduce pulse wave velocity in an anesthetized sheep model compared to atenolol?
Nebivolol, but not atenolol, increases arterial distensibility via a beta2 adrenoceptor-dependent NO release mechanism in an in vivo sheep model.
McEniery et al. (2004) studied this question.
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