Why the study?
Does nebivolol improve central blood pressure and augmentation index compared to atenolol in never-treated subjects with isolated systolic hypertension?
Population
16 never-treated subjects with isolated systolic hypertension
Comparison
Nebivolol 5 mg for 5 weeks vs Atenolol 50 mg for 5 weeks and placebo for 5 weeks
Design
RCT, randomized, cross-over study in a random order, double-blind
Follow-up
5 weeks per treatment arm
Authors
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Supports nebivolol preference over atenolol in isolated systolic hypertension; extends evidence for differential beta-blocker effects on central hemodynamics.
Does nebivolol improve central blood pressure and augmentation index compared to atenolol in never-treated subjects with isolated systolic hypertension?
Nebivolol reduces aortic pulse pressure more than atenolol in isolated systolic hypertension, likely due to less pronounced bradycardia and a smaller increase in augmentation index.
Dhakam et al. (2008) studied this question.
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