Key result
Nebivolol and atenolol both significantly reduced blood pressure (P<0.001), but atenolol significantly elevated mean blood sugar and lipid profiles (P<0.001) whereas nebivolol did not.
Why the study?
Does nebivolol improve metabolic parameters compared to atenolol in patients with essential hypertension?
Population
n=69 enrolled adults aged 18-60 years with essential hypertension. Key exclusions: blood pressure ≥180/110…
Comparison
Nebivolol 5 mg oral once daily for 24 weeks vs Atenolol 50 mg oral once daily for 24 weeks
Design
RCT, Randomly allocated using random number table, Open-label
Follow-up
24 weeks
Authors
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Nebivolol may be metabolically preferable to atenolol; leaves open need for larger trials before practice change.
RCT (n=69)
Open-label
parallel
Does nebivolol improve metabolic parameters compared to atenolol in patients with essential hypertension?
p-value: p=<0.001
Nebivolol provides similar antihypertensive efficacy to atenolol but avoids the adverse metabolic effects on blood sugar and lipid profiles associated with traditional beta-blockers.
Badar et al. (2011) conducted an RCT in essential hypertension (n=69). Nebivolol vs. Atenolol was evaluated on blood pressure, blood sugar, and lipid profile (p=<0.001). Nebivolol and atenolol both significantly reduced blood pressure (P<0.001), but atenolol significantly elevated mean blood sugar and lipid profiles (P<0.001) whereas nebivolol did not.
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