Why the study?
Does nebivolol improve tolerability and reduce blood pressure compared to atenolol in patients with mild-to-moderate essential hypertension?
Population
205 middle-age patients with mild-to-moderate essential hypertension
Comparison
Nebivolol 5 mg daily for 12 weeks vs Atenolol 100 mg daily for 12 weeks
Design
RCT, randomized, double-blind
Follow-up
12 weeks
Authors
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Nebivolol may be preferred over atenolol for better tolerability in hypertension; extends comparative beta-blocker data for practice and future trials.
Does nebivolol improve tolerability and reduce blood pressure compared to atenolol in patients with mild-to-moderate essential hypertension?
Nebivolol provides equivalent blood pressure reduction to atenolol in mild-to-moderate hypertension but with a better tolerability profile and fewer side effects.
Grassı et al. (2003) studied this question.
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