Effects of nebivolol and atenolol on central aortic pressure in hypertensive patients: A multicenter, randomized, double-blind study
Key result
Nebivolol produces a ~3% smaller change in augmentation index than atenolol at 10 weeks.
- MD 3.1%
- 95% CI 0.55-5.69
- P=0.027
- n=138
Why the study?
Does nebivolol improve augmentation index compared to atenolol in patients with mild to moderate essential hypertension?
Population
138 outpatients aged 40-65 years with mild or moderate essential hypertension across six Spanish centers.
Comparison
Nebivolol 5 mg once daily for 10 weeks, with… vs Atenolol 50 mg once daily for 10 weeks, with…
Design
RCT, Randomized into two groups of 69 patients each, Double-blind
Follow-up
10 weeks
Authors
Discussion
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Implication
Nebivolol alters augmentation index less than atenolol; challenges assumptions of superior vascular effects for nebivolol in hypertension.
Study Design
Type
RCT (n=138)
Blinding
double-blind
Randomization
randomized
Multicenter
Yes
Structured PICO
Does nebivolol improve augmentation index compared to atenolol in patients with mild to moderate essential hypertension?
P
Population
138 outpatients aged 40-67 years with mild or moderate essential hypertension, followed for 10 weeks.
I
Intervention
Nebivolol 5 mg once daily for 10 weeks, with optional addition of hydrochlorothiazide 25 mg after 6 weeks if normal blood pressure was not achieved.
C
Comparator
Atenolol 50 mg once daily (titratable to 100 mg once daily at week 3 for non-responders) for 10 weeks, with optional addition of hydrochlorothiazide 25 mg after 6 weeks if normal blood pressure was not achieved.
O
Outcome
Mean change in augmentation index at 10 weeks.surrogate
Main Result
Mean Difference: 3.1 (95% CI 0.55–5.69)
p-value: p=0.027
In patients with mild to moderate hypertension, nebivolol produced a less pronounced impact on augmentation index compared to atenolol over 10 weeks.
Cite This Study
Redón et al. (2013) conducted an RCT in mild or moderate essential hypertension (n=138). Nebivolol vs. Atenolol 50 mg once daily was evaluated on mean change in augmentation index (MD 3.1%, 95% CI 0.55-5.69, p=0.027). Nebivolol modified the mean augmentation index to a lesser extent than atenolol after 10 weeks (mean difference 3.1%; 95% CI 0.55-5.69; p=0.027).