Why the study?
Does nebivolol/hydrochlorothiazide improve aortic wave augmentation and central blood pressure compared to metoprolol/hydrochlorothiazide in patients with elevated blood pressure?
Does nebivolol/hydrochlorothiazide improve aortic wave augmentation and central blood pressure compared to metoprolol/hydrochlorothiazide in patients with elevated blood pressure?
In patients with elevated blood pressure, nebivolol combined with hydrochlorothiazide does not offer superior benefits over metoprolol combined with hydrochlorothiazide regarding aortic wave augmentation or central blood pressure.
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Nebivolol/HCTZ offers no central hemodynamic advantage over metoprolol/HCTZ; challenges presumed superiority of vasodilating beta-blockers on wave reflection.
Schattenkerk et al. (2013) studied this question.
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