What question did this study set out to answer?

July 23, 2018International Journal of Basic & Clinical PharmacologyOpen Access

A comparative study of effects of nebivolol and atenolol on blood pressure and lipid profile in patients of mild to moderate hypertension

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Why the study?

Does nebivolol improve lipid profile compared to atenolol in patients with mild to moderate hypertension?

Population

100 men and women aged 18-60 years with newly diagnosed mild to moderate hypertension. Exclusions included…

Comparison

Nebivolol 5 mg once a day orally for 24 weeks vs Atenolol 50 mg once a day orally for 24 weeks

Design

RCT, Simple random sampling (Chit-Pull method), Open labelled

Follow-up

24 weeks

Authors

MVMonali VakhariaSun Pharma Advanced Research (India)VZVijay ZadDr. V. M. Government Medical College NMNishikant Nandlal MankarDr. V. M. Government Medical College

Discussion

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Implication

Nebivolol may preserve lipids better than atenolol in mild hypertension; leaves open need for outcome trials before practice change.

Key Points

The study aims to compare the effects of nebivolol and atenolol on blood pressure and lipid profile in patients with mild to moderate hypertension.
Prospective, randomized, open labeled study with 100 patients enrolled.
Patients divided into two groups: 50 on atenolol and 50 on nebivolol.
Blood pressure and lipid profiles measured at baseline and after 24 weeks.
Atenolol therapy significantly increased LDL-C, VLDL-C, total cholesterol, and triglycerides after 24 weeks (p<0.0001).
HDL-C levels significantly decreased with atenolol therapy (p<0.0001).
Lipid profile changes with nebivolol therapy were not statistically significant (p>0.05).

Structured PICO

Does nebivolol improve lipid profile compared to atenolol in patients with mild to moderate hypertension?

Population

100 men and women aged 18-60 years with newly diagnosed mild to moderate hypertension (BP ≥140/90 to <180/110 mmHg). Exclusions included severe hypertension, secondary hypertension, diabetes mellitus, asthma/COPD, hepatic/renal diseases, heart failure, myocardial infarction, and patients on lipid lowering agents.

Intervention

Nebivolol 5 mg once a day orally for 24 weeks

Comparator

Atenolol 50 mg once a day orally for 24 weeks

Outcome

Mean change in blood pressure and LDL-C from baseline to final assessment at 24 weekssurrogate

Nebivolol and atenolol are equally effective in reducing blood pressure, but nebivolol has a more favorable lipid profile compared to atenolol, which worsens lipid parameters.

Limitations

Single-center study
Small sample size
Short duration of 24 weeks, unable to record long-term effects

Cite This Study

Vakharia et al. (2018) studied this question.

synapsesocial.com/papers/6a70c9c2e5469ee92be178f2 https://doi.org/10.18203/2319-2003.ijbcp20183018

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A comparative study of effects of nebivolol and atenolol on blood pressure and lipid profile in patients of mild to moderate hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

A comparative study of effects of nebivolol and atenolol on blood pressure and lipid profile in patients of mild to moderate hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

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