June 30, 2003European Journal of Heart Failure

β-Blocker Treatment of Patients with Diastolic Heart Failure and Arterial Hypertension. A Prospective, Randomized, Comparison of the Long-Term Effects of Atenolol Vs. Nebivolol

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Why the study?

Does nebivolol improve resting and exercise hemodynamic parameters and maximal exercise capacity compared to atenolol in patients with hypertension and diastolic heart failure?

Structured PICO

Does nebivolol improve resting and exercise hemodynamic parameters and maximal exercise capacity compared to atenolol in patients with hypertension and diastolic heart failure?

Population

26 patients with hypertension and left ventricular (LV) diastolic dysfunction (ejection fraction >50%, end-diastolic diameter <60 mm and increased pulmonary wedge pressure at rest and/or at peak exercise)

Intervention

Nebivolol administered for 6 months

Comparator

Atenolol administered for 6 months

Outcome

Resting and exercise hemodynamic parameters and maximal exercise capacity at 6 monthssurrogate

Nebivolol provides superior hemodynamic and exercise capacity improvements compared to atenolol in patients with hypertension and diastolic heart failure.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Favors nebivolol over atenolol for superior hemodynamics and peak VO2 in hypertensive diastolic HF; extends direct beta-blocker comparisons in this population.

Cite This Study

Nodari et al. (2003) studied this question.

synapsesocial.com/papers/6a07b63c7ba19a189e06b45d https://doi.org/10.1016/s1388-9842(03)00054-0

Topics

Heart failure HFrEF treatment Hypertension management Echocardiography

View Full Paper

Ask AI

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Implication

Favors nebivolol over atenolol for superior hemodynamics and peak VO2 in hypertensive diastolic HF; extends direct beta-blocker comparisons in this population.

β-Blocker Treatment of Patients with Diastolic Heart Failure and Arterial Hypertension. A Prospective, Randomized, Comparison of the Long-Term Effects of Atenolol Vs. Nebivolol

Structured PICO

Discussion

Implication

Cite This Study

Topics

β-Blocker Treatment of Patients with Diastolic Heart Failure and Arterial Hypertension. A Prospective, Randomized, Comparison of the Long-Term Effects of Atenolol Vs. Nebivolol

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider