September 1, 1990Angiology
Hemodynamic Effects of Nebivolol at Rest and on Exertion in Patients with Heart Failure
Why the study?
Does oral nebivolol 5 mg/day alter hemodynamic parameters at rest and on exertion in male patients with coronary artery disease and heart failure?
Population
10 male patients with coronary artery disease and heart failure (mean ejection fraction 46%)
Design
Cohort
Follow-up
7 days
Authors
Discussion
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Member takes
Implication
Supports nebivolol hemodynamic stability in HF; hypothesis-generating, needs RCT confirmation before practice change.
Structured PICO
Does oral nebivolol 5 mg/day alter hemodynamic parameters at rest and on exertion in male patients with coronary artery disease and heart failure?
P
Population
10 male patients with coronary artery disease and heart failure (mean ejection fraction 46%)
I
Intervention
Oral nebivolol 5 mg/day for 7 days
O
Outcome
Hemodynamic parameters (mean blood pressure, heart rate, pulmonary artery pressure, pulmonary wedge pressure, right atrial pressure, cardiac output, and stroke volume) measured at rest and on exertionsurrogate
Nebivolol can be used in heart failure patients without causing hemodynamic deterioration, as it maintains cardiac output and increases stroke volume.
Cite This Study
Brune et al. (1990) studied this question.