Key result
The combination of all three diabetes-related complications (retinopathy, nephropathy, and peripheral neuropathy) was associated with significantly lower multi-lag entropy and a higher odds ratio for altered LF/HF ratio (OR 4.92) compared to diabetic patients without complications.
Why the study?
Does the presence of diabetes-related complications reduce heart rate variability in patients with type II diabetes mellitus?
Cross-Sectional (n=169)
Yes
Does the presence of diabetes-related complications reduce heart rate variability in patients with type II diabetes mellitus?
The presence and combination of microvascular and neurological complications in type 2 diabetes are associated with progressive cardiac autonomic dysfunction as measured by multi-lag entropy of heart rate variability.
May signal greater autonomic dysfunction with triple diabetic complications; hypothesis-generating for HRV metrics and requires prospective validation.
Microvascular, macrovascular and neurological complications are the key causes of morbidity and mortality among type II diabetes mellitus (T2DM) patients. The aim of this study was to investigate the alterations of cardiac autonomic function of diabetic patients in relation to three types of diabetes-related complications. ECG recordings were collected and analyzed from 169 T2DM patients in supine position who were diagnosed with nephropathy (n = 55), peripheral neuropathy (n = 64) and retinopathy (n = 106) at two hospitals in the UAE. Comparison between combinations of patients with complications and a control diabetic group (CONT) with no complication (n = 34) was performed using time, frequency and multi-lag entropy measures of heart rate variability (HRV). The results show that these measures decreased significantly (p<0.05) depending on the presence and type of diabetic complications. Entropy, (median, 1st- 3rd interquartile range) for the group combining all complications (1.74,1.37-2.09) was significantly lower than the corresponding values for the CONT group (1.77, 1.39-2.24) with lag-1 for sequential beat-to-beat changes. Odds ratios (OR) from the entropy analysis further demonstrated a significantly higher association with the combination of retinopathy and peripheral neuropathy versus CONT (OR: 1.42 at lag 8) and an even OR for the combination of retinopathy and nephropathy (OR: 2.46 at lag 8) compared to the other groups with complications. Also, the OR of low frequency power to high frequency power ratio (LF/HF) showed a higher association with these diabetic-related complications compared to CONT, especially for the patient group combining all complications (OR: 4.92). This study confirms that the type of microvascular or peripheral neuropathy complication present in T2DM patients have different effects on heart rate entropy, implying disorders of multi-organ connectivity are directly associated with autonomic nervous system dysfunction. Clinical practice may benefit from including multi-lag entropy for cardiac rhythm analysis in conjunction with traditional screening methods in patients with diabetic complications to ensure better preventive and treatment outcomes in the Emirati Arab population.
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Khandoker et al. (2017) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=169). Diabetes-related complications (retinopathy, nephropathy, peripheral neuropathy) vs. Diabetic patients without complications was evaluated on Multi-lag entropy (lag-1) (p=<0.05). The combination of all three diabetes-related complications (retinopathy, nephropathy, and peripheral neuropathy) was associated with significantly lower multi-lag entropy and a higher odds ratio for altered LF/HF ratio (OR 4.92) compared to diabetic patients without complications.
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