Why the study?
Does transgenic ACE2 overexpression in vascular smooth muscle cells reduce blood pressure and improve endothelial function in SHRSP rats?
Does transgenic ACE2 overexpression in vascular smooth muscle cells reduce blood pressure and improve endothelial function in SHRSP rats?
Vascular ACE2 overexpression reduces hypertension and improves endothelial function in a rat model, suggesting the ACE2/angiotensin-(1-7) axis as a potential therapeutic target.
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Hypothesis-generating for ACE2-targeted hypertension therapies; leaves open translation from rat models to clinical use.
Rentzsch et al. (2008) studied this question.
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