March 30, 2004Physiological Genomics

Expression of an angiotensin-(1–7)-producing fusion protein produces cardioprotective effects in rats

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Why the study?

Does chronic overproduction of ANG-(1-7) produce cardioprotective effects in rats?

Structured PICO

Does chronic overproduction of ANG-(1-7) produce cardioprotective effects in rats?

Population

Transgenic rats (TGR(A1-7)3292) and nontransgenic control rats

Intervention

Chronic overproduction of angiotensin-(1-7) [ANG-(1-7)] using a cytomegalovirus promoter-driven transgene

Comparator

Nontransgenic control rats

Outcome

Hemodynamic measurements (heart rate, cardiac contractility), resistance to isoproterenol-induced cardiac hypertrophy, duration of reperfusion arrhythmias, and postischemic functionsurrogate

Chronic overproduction of ANG-(1-7) in a novel transgenic rat model demonstrates significant cardioprotective effects against hypertrophy and ischemia-reperfusion injury.

Discussion

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Implication

Supports ANG-(1-7) cardioprotection in rat models; leaves open translation to human therapy.

Cite This Study

Santos et al. (2004) studied this question.

synapsesocial.com/papers/6a799131756812e395892152 https://doi.org/10.1152/physiolgenomics.00227.2003

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