Key result
Transgenic rats expressing the human angiotensinogen gene demonstrated sustained hypertension (systolic blood pressure 136 vs 127 mmHg, P<0.001) and a fourfold increase in cardiac angiotensin II.
Why the study?
Does increased human angiotensinogen gene expression alter heart function and arterial pressure in transgenic rats?
Population
Male homozygous transgenic rats harboring the human angiotensinogen gene [TGRL1623] and Sprague-Dawley…
Comparison
Expression of the human angiotensinogen gene vs Sprague-Dawley (SD) control rats
Design
Preclinical
Authors
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Does not support clinical translation; extends preclinical models of renin-independent cardiac ANG II formation.
Does increased human angiotensinogen gene expression alter heart function and arterial pressure in transgenic rats?
Absolute Event Rate: 136% vs 127%
p-value: p=<0.001
Transgenic rats expressing the human angiotensinogen gene exhibit hypertension and cardiac hypertrophy driven by a non-renin-dependent increase in cardiac ANG II, providing a novel model for studying renin-independent cardiac ANG II formation.
Ferrario et al. (2016) studied Hypertension (n=20). Human angiotensinogen (hAGT) gene expression vs. Sprague-Dawley (SD) control rats was evaluated on 24-hour average systolic blood pressure (mmHg) (p=<0.001). Transgenic rats expressing the human angiotensinogen gene demonstrated sustained hypertension (systolic blood pressure 136 vs 127 mmHg, P<0.001) and a fourfold increase in cardiac angiotensin II.
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