Key result
Surgically induced mesenteric venous hypertension significantly reduced the contraction frequency (2.98 vs 5.42 min-1) and fractional pump flow of postnodal mesenteric lymphatic vessels compared to sham surgery after 3 days.
Postnodal mesenteric lymphatic vessels adapt to mesenteric venous hypertension by reducing intrinsic contractile activity within 3 days.
Suggests rapid lymphatic adaptation to venous hypertension in rodents; human relevance and therapeutic implications remain to be tested.
Lymph flow is the primary mechanism for returning interstitial fluid to the blood circulation. Currently, the adaptive response of lymphatic vessels to mesenteric venous hypertension is not known. This study sought to determine the functional responses of postnodal mesenteric lymphatic vessels. We surgically occluded bovine mesenteric veins to create mesenteric venous hypertension to elevate mesenteric lymph flow. Three days after surgery, postnodal mesenteric lymphatic vessels from mesenteric venous hypertension (MVH; n = 7) and sham surgery (Sham; n = 6) group animals were evaluated and compared. Contraction frequency (MVH: 2.98 ± 0.75 min(-1); Sham: 5.42 ± 0.81 min(-1)) and fractional pump flow (MVH: 1.14 ± 0.30 min(-1); Sham: 2.39 ± 0.32 min(-1)) were significantly lower in the venous occlusion group. These results indicate that postnodal mesenteric lymphatic vessels adapt to mesenteric venous hypertension by reducing intrinsic contractile activity.
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Quick et al. (2014) studied Mesenteric venous hypertension (n=13). Surgically induced mesenteric venous hypertension vs. Sham surgery was evaluated on Contraction frequency of postnodal mesenteric lymphatic vessels (min-1) (p=<0.05). Surgically induced mesenteric venous hypertension significantly reduced the contraction frequency (2.98 vs 5.42 min-1) and fractional pump flow of postnodal mesenteric lymphatic vessels compared to sham surgery after 3 days.
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