June 1, 2003AJP Regulatory Integrative and Comparative Physiology

Myogenic responses and compliance of mesenteric and splenic vasculature in the rat

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Population

Mesenteric and splenic arterioles and venules from rats anesthetized with pentobarbital sodium

Comparison

Raising intraluminal pressures with or without… vs Baseline intraluminal pressures

Design

Preclinical

Authors

ZBZoë BrookesUniversity of Plymouth SKSusan KaufmanUniversity of Alberta

Discussion

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Implication

Rodent arteriolar differences should not inform clinical splanchnic management; extends regional NO-myogenic control mechanisms.

Structured PICO

Population

Mesenteric and splenic arterioles (~150-200 microm) and venules (<250 microm) from rats anesthetized with pentobarbital sodium

Intervention

Raising intraluminal pressures (80 to 120 mmHg for arterioles, 4-8 mmHg for venules) with or without N(omega)-nitro-l-arginine methyl ester (l-NAME)

Comparator

Baseline intraluminal pressures

Outcome

Change in vessel diameter (myogenic response and compliance)surrogate

Mesenteric arterioles exhibit myogenic responses that limit flow changes, whereas splenic vessels lack this response due to NO-mediated dilation, facilitating fluid extravasation.

Cite This Study

Brookes et al. (2003) studied this question.

synapsesocial.com/papers/6a83fc3120cfb2932ffe3078 https://doi.org/10.1152/ajpregu.00411.2002

View Full Paper

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Bookmark

Myogenic responses and compliance of mesenteric and splenic vasculature in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myogenic responses and compliance of mesenteric and splenic vasculature in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider