Key result
Glucose, insulin, and potassium (GIK) therapy showed no effect on progression to infarction in patients with suspected myocardial ischemia, though secondary endpoints trended in favor of treatment.
Why the study?
Does glucose, insulin, and potassium (GIK) therapy prevent progression to infarction in patients with suspected myocardial ischemia?
Population
Patients with suspected myocardial ischemia / acute coronary syndrome
Design
Editorial
Authors
Discussion
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Member takes
Implication
Early administration of GIK in suspected myocardial ischemia did not prevent progression to infarction, though trends in secondary endpoints suggest the need for further definitive studies.
Structured PICO
Does glucose, insulin, and potassium (GIK) therapy prevent progression to infarction in patients with suspected myocardial ischemia?
P
Population
Patients with suspected myocardial ischemia / acute coronary syndrome
I
Intervention
Glucose, insulin, and potassium (GIK) therapy administered early (preferably within the first hour from onset of symptoms) in the setting of emergency medical services
O
Outcome
Progression to infarctionhard clinical
Early administration of GIK in suspected myocardial ischemia did not prevent progression to infarction, though trends in secondary endpoints suggest the need for further definitive studies.
Limitations
- The trial fell far short of its enrollment goals, necessitating a reconfiguration of the primary endpoint.
- Secondary endpoints were evaluated with an alpha level of .05 for each hypothesis, raising concerns about multiple hypothesis testing and random noise.
- Fell far short of enrollment goals
- Reconfigured primary end point
- Multiple hypothesis testing for secondary endpoints without appropriate statistical adjustment
Cite This Study
Robert M. Califf (2012) conducted an editorial in Suspected myocardial ischemia. Glucose, insulin, and potassium (GIK) was evaluated on Progression to infarction. Glucose, insulin, and potassium (GIK) therapy showed no effect on progression to infarction in patients with suspected myocardial ischemia, though secondary endpoints trended in favor of treatment.